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[14] successfully isolated exendin-4 from the venom of the Gila monster (Heloderma suspectum), a lizard known for its infrequent but large meals weighing up to as much as one third of its body masssuggesting the presence of adaptive metabolic mechanisms in the species [14,15]
On the contrary, arsenic- and mercury-treated cells strongly depleted mutants lacking the glutathione reductase GSR , which is involved in the regeneration of glutathione and therefore required for the extrusion of glutathionemetal conjugates by ABCC1 (Leslie et al, 2004)