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When it was found that foods containing NAD+ precursors, particularly vitamin B3, may treat the fatal illness pellagra, which is characterized by diarrhea, dermatitis, dementia, and death, the clinical significance of maintaining NAD+ levels was established in the early 1900s
The calibration curve was used to interpolate/extrapolate means as well as upper and lower bounds expressed in GSH concentration per time point
Oxidative stress increases with age, can lead to apoptosis, and can affect cognitive integrity (Grimm and Eckert, 2017