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Credit: Steven Levitte When these distended macrophages cant move into the TB granuloma, adds co-author Steven Levitte from the University of Washington, the infected macrophages that are already in there burst, leaving a soup in which the bacteria can grow and spread further, making the infection worse. The researchers looked at whether the effect seen in the lysosomal deficiency disorders, where the clogged-up macrophage could no longer perform its work, would also be observed if the lysosome became clogged up with non-biological material