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Hypoxia promotes the expression of immunosuppressive molecules such as vascular endothelial growth factor (VEGF), TGF-, IL-10, and PD-L1 and induces the recruitment of cancer-associated fibroblasts (CAF) to facilitate the infiltration of myeloid-derived suppressor cells (MDSCs), Tregs, and type 2 tumor-associated macrophages (TAMs) via hypoxia-induced metabolic alterations in the tumor and TME [254, 255]

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GLOBOCAN 2000: Cancer Incidence, Mortality and Prevalence Worldwide Version 1.0