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Mouse models have also confirmed that e-cigarettes increase immune cells like macrophages and neutrophils, as well as multiple COPD-related cytokines, including CCL2, IL-4, IL-13, IL-10, M-CSF, and TNF-

Each ZYN pouch contains four key components: Pharmaceutical-grade nicotine Plant-based fibers (as fillers) pH adjusters Food-grade flavoring Unlike traditional tobacco products, ZYN contains zero tobacco leaf, stem, or dust

Consider health equity impacts

Cigarette burning in a smoker's mouth