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That changed in 2025 with the publication of SURMOUNT-5, the first randomized head-to-head trial, published in the New England Journal of Medicine

Heart palpitations feel like the heart is beating too fast, skipping beats, or pounding harder than usual

Wharton S, Lingvay I, Bogdanski P, et al

These results come weeks after a preliminary review by the Food and Drug Administration (FDA) that found no evidence linking weight loss drugs to suicidal thoughts

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