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As expected, the rate of 13 C-CR formation from 13 C-glucose increased progressively after 1 complete cell cycle (Figure 4D), and resembled the time course of CR formation from creatinine (Figure 2, B and C, and Figure 3K), confirming that the ribosylation of creatinine was the rate-limiting step in CR formation

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A slow mode of delivery is ingestion, such as drinking alcohol