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Califf, M.D., FDA Commissioner said

Finally, it is important to note that, because TRPA1 and TRPV1 are co-expressed on sensory neurons, there is a possibility these TRP channels act in concert to elicit functional responses to noxious stimuli

One of the most common presentations in my clinic was viral smell loss, before COVID-19 came along, but its just the sheer scale of it with COVID-19 that has made it so dramatic and turned the spotlight on it in quite a way that we havent seen possible before. It is estimated that about two-thirds of patients experience loss of smell during acute COVID-19 and about 1015% of these report persistent symptoms for more than four weeks[2]

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To get the hell out of there