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Allelic association studies have focused in particular on the alleles of genes that affect alcohol metabolism because, as we have already seen, people with impaired activity of the alcohol-metabolizing enzyme, aldehyde dehydrogenase, have unpleasant reactions when they consume alcohol, and are therefore at significantly lower risk of alcohol dependence

Recently popularized theories on the evolution of human behavior also support the idea of dichotomy, with women depicted as nonaggressive and therefore prone to be exploited and abused

Developing educational campaigns and informing practitioners about caveats around ENDS as cessation or harm reduction aids are critical

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Furthermore, many of those who begin using e-cigarettes (vaping), end up doing so in addition to, and not instead of regular cigarettes