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Statistical analysis Statistical analyses were performed using IBM SPSS Statistics 23.0 (IBM, USA)

The most common adverse effects are gastrointestinal, occurring in 20-40% of patients, including nausea, diarrhea, vomiting, constipation, and abdominal pain

DSIP (Delta Sleep-Inducing Peptide) is a neuropeptide investigated in experimental models for its involvement in sleep regulation and circadian rhythm signaling

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coli Nissle 1917 ameliorates mitochondrial injury of granulosa cells in polycystic ovary syndrome through promoting gut immune factor IL-22 via gut microbiota and microbial metabolism