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Heavy and prolonged use of both is dangerous and can lead to significant consequences, such as alcohol use disorder, cannabis use disorder, and other physical and mental health complications

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"But as a harm reduction strategy, making products that don't contain tobacco or contain very small amounts of tobacco available will likely result in a reduction of some of the significant tobacco-related morbidity and mortality that we see." These effects are all theoretical until the proposed rule becomes official

People who reported daily marijuana use had a 34% increased risk of developing heart failure, compared to those who reported never using marijuana

[7] Using smokeless tobacco can cause various harmful effects such as dental disease, oral cancer, oesophagus cancer, and pancreas cancer, coronary heart disease, as well as negative reproductive effects including stillbirth, premature birth and low birth weight