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These women should be considered "at risk" and provided with ongoing support

In support of this, reduced expression of mRNAs coding for bone matrix proteins such as bone sialoprotein (BSP), osteopontin, and osteonectin were also observed with chronic nicotine exposure [24]

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According to Reddy, studies have found that HIV infection independently increases the risks for developing serious medical outcomes such as heart attacks, emphysema and lung cancer that are already associated with smoking, making HIV infection and smoking a particularly dangerous combination

Impaired endothelial function, arterial stiffness, increased inflammation, lipid alteration, and prothrombotic factors are associated with smoking and appear to initiate as well as accelerate the atherothrombotic process, eventually leading to cardiovascular events 3