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Studies about these five autophagy receptors were knocked out by CRISPR-Cas9 in cells indicated that only NDP52 and OPTN are primarily essential for mitophagy, which may be due to the function of NDP52 and OPTN in growing the isolation membrane to amplify mitophagy through an NDP52/OPTN-Ulk1-ATG8-NDP52/OPTN-dependent positive feedback loop, as NDP52 and OPTN have lower binding affinity to all ATG8 family proteins compared to P62 and NBR1

Over the years, Norma has managed to maintain the illusion of dominance, mostly because everyone tiptoes around the fact that shes cuckoolicious

But what if the story is more complicated

Mary's Hospital reached these findings