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Even more, long-term exposure to CSE causes more complex changes in mitochondrial morphology, reflecting the coexistence of different mitochondrial phenotypes, both elongated and fragmented, to different levels of chronic cigarette smoke in COPD ( CS is also known to enhance respiratory disorders such as bronchitis and asthma, characterized by inflammatory changes, hyperresponsiveness, and increased cell proliferation of airway smooth muscle (ASM) (53)