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Interestingly, the combination of PIO with DAPA showed the biggest reductions of hepatic tissue inhibitor of metalloproteinase 1 (TIMP-1) concentrations

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The mechanism centers on upregulation of vascular endothelial growth factor (VEGF) and fibroblast growth factor (FGF-2), both critical for angiogenesis and collagen synthesis during the proliferative phase of soft tissue healing

doi: 10.1146/annurev-biochem-060815-014830 42