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How These Layers Connect Rather than viewing each of these fungal factors in isolation, its more helpful to see them as overlapping layers of stress on the immune system

Metabolites and pathways were grouped into three modules reflecting recurrent biochemical patterns across domains: kynurenine/tryptophan pathway ( Figure S2C ), methionine (one-carbon and sulfur) metabolism ( Figure S2D ), and -alanine/CoA/pyrimidine metabolism ( Figure S2E )

A comparison with nonselective adrenergic agonists highlights albuterols selectivity, relative resistance to catechol-O-methyltransferase (COMT) metabolism, and primary use in acute asthma rescue therapy

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