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In its decision, the agency noted that the Moonlight and Moonlight Menthol cigarette products differ from conventional cigarettes in nicotine content only the products share similar adverse health risks as conventional cigarettes

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Studies, including the Women's Ischemia Syndrome Evaluation (WISE), suggest that microvascular angina is part of the pathophysiology of ischemic heart disease, perhaps explaining the higher rates of angina in females than in males, as well as their predilection towards ischemia and acute coronary syndromes in the absence of obstructive coronary artery disease