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Conversely, in an environment where conformity to social and cultural norms holds less weight, such as the US, smoking prevalence between genders is more even, with less than a 6% difference between men and women (59)

One of these methods, according to critics, was the addition of reconstituted tobacco waste

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While the study did not assess the levels of urine cotinine or carboxyhemoglobin, we selected CO as a biological marker because it is simple and quick to measure, less expensive than a battery of laboratory tests, and noninvasive, making it more agreeable to the subjects as reported by Middleton et al