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Currently, the small application range of targeted therapy drugs and recurrence and drug resistance after radiotherapy and ablation treatment lead to the unoptimistic overall treatment effect of advanced liver cancer, and the 5-year survival rate is low (Schlachterman et al., 2015)

Constipation , diarrhea , sulfur burps , and acid reflux are common, especially during dose escalation

Pretreatment by low-dose fibrates protects against acute free fatty acid-induced renal tubule toxicity by counteracting PPARalpha deterioration

Long-term exposure to heat, light, or moisture may reduce peptide stability and should be avoided

NNMT is a cytosolic enzyme that regulates energy balance in adipose tissue