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Similar mechanisms have been implicated in pulmonary arterial hypertension (PAH), where FUT8-mediated fucosylation of growth factor receptors, including VEGFR, activates PI3K/AKT pathways, contributing to vascular remodeling and smooth muscle proliferation [103]

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23 Cotinine is present in the blood higher than nicotine and concentrations of nicotine and cotinine in urine are tenfold to hundred fold greater than in plasma and saliva

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