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304 After binding to mtDNA accumulated in the cytoplasm, cyclic GMP-AMP synthase (cGAS) is activated and produces 2'3'-cGAMP, a second messenger, which in turn leads to the dimerization of STING and the activation of downstream TBK1

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The complete cDNA was 1270 bp in length and contained an open reading frame of 1098 bp encoding a 365-amino-acid MMP named NtMMP1 (Figure 1)