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Adjustments for potential confounding and modelling strategy

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Given that only 9.8 % of current smokers in Canada used roll-your-own cigarettes in 2010, and that this statistic is not reportable in Ontario due to small numbers, we do not feel that this would have biased our results [35]

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This study indicates that nicotine could be beneficial for conditions mediated by chronic neuroinflammation such that delineating the neural mechanism mediating these effects could lead to targeted therapeutics for both neuroinflammation and cognitive symptoms in PLWH