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Long-term exposure to air-borne irritants including tobacco smoke, marijuana smoke, air pollution and other chemical fumes and dust are the main factors that cause the obstructive pulmonary disease

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This study was supported by the grants from the Smoking Research Foundation, the Grants-in-Aid for Scientific Research from the Ministry of Education, Culture, Sports, Science and Technology in Japan (23590295 and 15K00809), and the Takeda Science Foundation

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