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SIENA is a statistical modeling technique designed for the analysis of longitudinal network data collected in a panel study with two or more time-points (Mercken et al., 2009, 2012

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doi: 10.1186/1617-9625-12-S1-A34 73

[158] A 2016 study reported that some e-liquids contained tobacco alkaloids such as nornicotine, anabasine, anatabine, and TSNAs, such as N -nitrosonornicotine (NNN), 4-(methylnitrosamine)-1-(3-pyridyl)-1-butanone (NNK), [15] nitrates, and phenol