In a recent multi-arm trial by Satapathy et al., participants with T2D in one arm of the trial (n = 20) received 500 mcg/day of methylcobalamin for eight weeks 43
All of the ingredients in our injections specifically can be found on our website
For maintenance or prophylactic use (such as in a patient with short-gut syndrome who cannot absorb oral vitamins well), a common regimen is 1 mL IM once weekly
It is likely that the larger number of statistically significant changes to the microbiome observed in the groups switched from WD to LD reflects their more numerous exposures to different diets, longitudinal changes in dietary exposure, the stress associated with diet switch, the negative energy state achieved by treatment and/or diet-driven weight loss, or a combination of these factors, but it may also be related to differences in terminal body weight and fat mass since both adiposity and diet composition have been shown to modulate the mouse gut microbiome profile
The half-life is approximately 46 hours in rodent models, meaning systemic concentration peaks and declines within a predictable window