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Following a week of acclimatization, all the rats ( n = 50) were randomly assigned into NF, HF, HF + Met, HF + L-car, and HF + met + L-car groups ( n = 10 per group)

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In terms of treatment, some studies suggest that lipoprotein apheresis could raise the risk of depression [153], so careful monitoring of the mental status of patients undergoing this therapy is recommended

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