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Figure 2 / Smoking prevalence and tobacco tax revenue under different scenarios Source: Authors calculations

Japan Tobacco's Ploom X Advanced targeted women aged 30-45 through collaborations with fashion brands and limited-edition device skins, generating 31% of the product line's 2025 revenue from women, despite their 12% share of Japan's smoking population

What we found, says Hillel Alpert, is that they added ingredients particularly pyrazines that appear to have contributed to the smooth flavor, reducing the harshness of certain cigarettes. Pyrazines are also being added to e-cigarette fluids, his team wrote online June 10 in Tobacco Control

E-cigarettes as a source of toxic and potentially carcinogenic metals

In this case federal laws apply and it is still not legal on a federal level in the US