effects of tobacco alcohol and other harmful substances Smoking harms not just your physical health, but your mental health too The Many Dangers of Tobacco

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Big Tobacco gave away free cigarettes to psychiatric facilities People with mental health conditions and substance use disorders are a large customer base for the tobacco industry

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Compared with traditional meta-analysis using linear mixed effect models, MR-BRT relaxes the assumption of a log(linear) relationship between exposure and risk, incorporates between-study heterogeneity into the uncertainty of risk estimates, handles estimates reported across different exposure categories, automatically identifies and trims outliers, and systematically tests and adjusts for bias due to study designs and characteristics