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MR analyses of the effect of liability to bipolar disorder on smoking heaviness (beta IVW = 0.028, 95% CI 0.0030.053, P = 2.9 10 2 ) showed significant small effects for IVW and MR-RAPS but not weighted median or weighted mode (Table 1, supplementary Figs 1315)

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While this is generally safe, its only safe when the blood vessels are healthy

Increased strain on kidneys