Importantly, the RWE largely involved patients with type 2 diabetes a population already responsive to GLP-1 RAs
Ghrelin increases, leptin decreases, and insulin sensitivity worsens, leaving you hungrier, less satisfied after meals, and more prone to blood sugar swings that trigger additional cravings
Strength training while on semaglutide can lead to simultaneous fat loss and muscle gain, especially if you're new to resistance training
For broader peptide storage guidance , see our complete reference
Meet our doctors Last reviewed: 19 Jun 2026 Sources Glucagon-like peptide-1 (GLP-1): a gut hormone of potential interest in the treatment of diabetes, Bioessays [accessed 05 March 2026] Obesity Treatment (2023), NHS [accessed 05 March 2026] Semaglutide, National Institute for Health and Care Excellence [accessed 05 March 2026] Wegovy dosing schedule, Wegovy.com [accessed 05 March 2026] Wegovy (semaglutide): a new weight loss drug for chronic weight management, BMJ [accessed 05 March 2026] Weight loss injections NHS weight loss injections GLP-1 for weight loss Can doctors help with weight loss
