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Nonetheless, considering the strong association between the structural and functional abnormalities in the anterior insular cortex and what we have defined as a compulsive tobacco smoking behavior (in line with the previously cited preclinical, neuroimaging, and lesion studies) and by also considering the correlation between early-onset smoking and heaviness of tobacco smoking during adulthood (36), future research should aim at investigating the theoretical model proposed in this paper by: Replicating our structural neuroimaging findings by recruiting a larger sample size and by utilizing neurocognitive tasks assessing the multifaceted nature of compulsivity (an example could be the Intra-External Dimensional Shift task, which is a computerized test designed to assess for cognitive inflexibility), response inhibition, interoceptive awareness, and the compulsive smoking behavior of participants by utilizing measures such as the CDS