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3.2.2.1 Curcumin Curcumin, the bioactive compound extracted from turmeric , shows the potent therapeutic effects in various diseases including renal IRI, shock and myocardial ischemia with its antioxidant properties ( via the activation of Nrf2, Sirtuin-1 and Sirtuin-3 ( via inhibiting Keap1, upregulating Nrf2 and inducing the nuclear translocation of Nrf2 ( via Sirtuin-1-Nrf2-ARE signaling pathway ( via Nrf2 to ameliorate mitochondrial oxidative stress, and further restore the activities of renal mitochondrial respiratory enzyme in various kidney diseases ( 3.2.2.2 Resveratrol Besides promoting mitochondrial biogenesis, resveratrol also attenuates mitochondrial dysfunction and restores renal function via other multiple mechanisms

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