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Nephrol Dial Transplant 20:28362838 Frantzi M, Bhat A, Latosinska A (2014) Clinical proteomic biomarkers: relevant issues on study design and technical considerations in biomarker development

For instance, titanium dioxide, previously regarded as a safe additive, has recently been implicated in genotoxicity, raising concerns about its safety

This temporary dysfunction triggers an energy crisis in the brain, as blood flow and oxygen levels drop while inflammation increases

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Together, this multifactorial dilemma stipulates the necessity for the field to investigate novel pharmaceuticals and to extend the therapeutic utility of well-researched drugs already used in clinical practice