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This higher activity results from the insensitivity of ETC to FCCP treatment and is consistent with the limited reserve capacity of Gclc -deficient FoB (Fig

Alamanos Y, Drosos A

Briefly, binary masks of Synaptophysin and PLA positive regions were obtained by subtracting the background (rolling ball radius 10 pixels), applying a 1 sigma radius Gaussian blur filter on Synaptophysin signal and setting a user-defined threshold

As can be seen in Figure 1 , patients receiving CET demonstrated significant and large improvements across the domains of Neurocognition, Processing Speed, Cognitive Style, and Social Cognition, after two years of treatment