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It also evaluates novel therapeutic strategies that target iron dysregulation and senescence pathways

Graves disease: Graves disease is another autoimmune condition of the thyroid characterized by the production of TSIs that acts on TSH receptors found on the plasma membrane of thyroid follicular cells, triggering an excessive response by inducing a surge in secretion that eventually causes hyperthyroidism (Bartalena et al

1997), and mice with a humanized PPAR- receptor have a markedly reduced incidence of liver tumors compared with wild-type littermates (Morimura et al

fluid retention, which causes swelling in the extremities

Rejuvenation by therapeutic elimination of senescent cells