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It has been demonstrated in numerous in vivo and in vitro investigations that nicotine reduces the levels of IL-1B, IL-2, IL-8, IL-10, and TNF- in colorectal mucosa and blood mononuclear cells [50]

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In vitro studies have shown that activation of MRGPRX2 or its murine ortholog MrgprB2 induces MCs degranulation via Orai channels, with Orai1 and Orai2 being the predominant contributors

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