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During the process of mitophagy, LC3 adaptor proteins exert a bridge-like connecting role, binding to ubiquitinated cargo through the ubiquitin-binding domain (UBD) motif on one side, recognizing and binding to LC3 on the autophagosome membrane through the LC3-interacting region (LIR) motif on the other side (Stolz et al., 2014) (Figure 1A)

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