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Increased Nicotine Intake Many people who roll their own cigarettes tend to make them thicker, which can increase nicotine intake compared to pre-packaged cigarettes

Keith, "Supervisor of Physical Chemistry" for Liggett & Myers, who developed it)- the middle section of which contains small charcoal granules, which purportedly reduces the harshness of the cigarette's smoke

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doi:10.1093/ntr/ntq203

[48] A 2018 in vitro study found that exposing lung cells to liquid or vapor containing cinnamaldehyde causes significant and rapid damage to their cilia and mitochondria