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2Chest Pain If you smoke and have chest pain that worsens when you laugh, cough or breathe deeply, it could be a sign of heart disease such as arteriosclerosis (hardening of the arteries) or atherosclerosis, a type of arteriosclerosis in which a buildup of plaque in your blood vessels can lead to a dangerous clot

COPD and lung cancer often have overlapping symptoms, such as chronic cough, shortness of breath and chest discomfort

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For example, research published in Nature Medicine demonstrated that nicotine stimulates the vagus nerve, and, by extension, nicotinic receptors, reducing inflammatory cytokine production in models of sepsis

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