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Consequently, safety concerns exist regarding e-cigarette user exposure to harmful and potentially harmful constituents (HPHCs), including nicotine, which has the potential to cause addiction and other adverse events [14]

The relative importance of cigarette smoking in the development of CHD in young men (less than 50 years old) is greater than that for any other risk factor

FDA News Release: FDA Takes Action on Applications Seeking to Market Modified Risk Tobacco Products