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In addition to its association with increased mortality, CVDs, and graft failure, pre-transplant DM is also linked to a higher risk of impaired wound healing and infections [11, 12]

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Br J Cardiol 2011;18:247

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Enzymatic Digestion Although trypsin is the standard protease, Semaglutides structure required alternative enzymes due to limited cleavage sites: Chymotrypsin was chosen to cleave at aromatic residues (e.g., Phe, Tyr, Trp)