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95% CI, 1.62-2.73).45 Furthermore, it has been determined that the efficacy of this medication is related with dose, and with mean plasma concentrations of the drug and its metabolites.46 Smokers who use bupropion at doses of 100, 150 or 300 mg/day are respectively 1.42, 1.69 and 2.84 times more likely to stop smoking than those who receive placebo.46 Moreover, it has been established that the likelihood of the subject stopping smoking increases 1.01 times for every 1 g/L increase in the plasma concentrations of the metabolites of bupropion.46 Finally, in a meta-analysis of 10 randomized controlled trials involving 3800 smokers carried out by the National Institute for Clinical Excellence, the OR for successful smoking cessation of bupropion versus placebo was 2.16 (95% CI, 1.51-3.10).13 In other words, 19% of smokers who received bupropion were completely abstinent on follow up at 1 year, as compared to only 9% of those who received placebo.13 Bupropion should be used for a period of 7 to 9 weeks at a dosage of 300 mg/day taken as 150 mg twice daily Treatment should be started 7 to 15 days before the subject definitively stops smoking