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Co-administration of an OCT2 inhibitor, cimetidine (300 mg four times daily), with varenicline (2 mg single dose) to 12 smokers increased the systemic exposure of varenicline by 29% (90% CI: 21.5%, 36.9%) due to a reduction in varenicline renal clearance

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Keep sealed in a cool, dry place to maintain freshness.

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[22] Patch [edit] The patches provide slow absorption of nicotine into blood within the day and work for 16 hours