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[14] as noted above did not find EC use to be significantly associated with prevalence of functionally important respiratory symptoms (as noted in the section above), they did find exclusive EC use to be associated with worsening of functionally important respiratory symptoms in some analyses, though it depended on the exact cutoff used to denote functionally-important (i.e., 2 vs 3 on a 9-point scale) [14]

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The research team found mutational signatures, or molecular fingerprints of DNA damage, in the smokers DNA, counting how many of these specific mutations were found in the different tumors

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