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Even in 1960 following a decade of reports and research which demonstrated the negative consequences of smoking only one-third of doctors in the United States believed the case against cigarettes had been established

J Am Soc Nephrol JASN 15:S58S63 Xia J, Wang L, Ma Z et al (2017) Cigarette smoking and chronic kidney disease in the general population: a systematic review and meta-analysis of prospective cohort studies

E-cigarettes were generally considered to be satisfying to use

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Flavor then acts as a selection variable that determines where adoption clusters, with Regular variants often supporting baseline coverage and Menthol, Clove, and Fruit Flavors driving targeted trials and preference-led repeat cycles