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The data also demonstrates higher average costs ($23,278 versus $19,090) for the 16 cases reporting LITT of brain, and lower average costs for the 1 case reporting LITT of brain stem ($10,222 versus $19,090), as compared to the average costs of all cases in MS-DRG 041

In particular, cigarette smoke was found to induce alveolar macrophages and neutrophils to produce pro-inflammatory cytokines, reactive oxygen species, matrix metalloproteinases, and various chemokines 31

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