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Growing evidence suggests that p53 is a transcription factor that is activated by multiple different stresses, including DNA damage, oncogene activation, oxidative stress, and disruption of nucleolar function ( Although these findings demonstrated the key role of p53 in Parkin-dependent mitophagy, to the best of our knowledge, the exact mechanism whereby p53 controls mitochondrial homeostasis remains unclear

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By then, he had become a major movie and television star doing four films, and numerous television programs with Lucille Ball