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2010, Neurobiological mechanisms involved in nicotine dependence and reward: participation of the endogenous opioid system. This neurotransmitter release results in feelings of pleasure and reward, reinforcing the addictive nature of tobacco use

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1 PRISMA 2020 flow diagram for an updated systematic review of the Smoking and Tracheal, bronchus, and lung cancer risk-outcome pair

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Since their introduction to the market, electronic cigarettes have been considered a safer alternative to combustible tobacco products