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Additionally, our immunohistochemistry studies showed a significant reduction in CD45 staining across all TLR KO mouse models, further supporting a decrease in pro-tumor inflammatory TME of these mice ( Supplementary Figure S3F, G )

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Bone marrow aspiration and biopsy : The removal of bone marrow, blood, and a small piece of bone by inserting a hollow needle into the hipbone or breastbone

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