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North America is expected to expand at the fastest CAGR of 4.7% from 2021 to 2028, due to the growing popularity of roll-your-own tobacco cigarettes among students, young adults, and the female population

45 The findings that dual users of cigarettes and e-cigarettes have worse HRQoL than 5-year cessation may reflect the fact that these persons tend to be heavier, more dependent smokers 46 compared to 5-year cessation, many of whom may not have been heavy cigarette smokers to begin with

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Those with higher nicotine tolerance may opt for strengths up to 24 mg/mL for a more satisfying experience

These include mild swelling, tenderness when brushing, and a shiny or tight appearance of the gums